While lower-rely MBL not often progresses to CLL, substantial-depend MBL progresses to CLL demanding therapy in a rate of 1% to 2% per year. Significant-depend MBL is distinguished from Rai 0 CLL according to if the B-cell rely is higher than or down below five × 109/L. While people with both equally large-count MBL and CLL Rai phase 0 are at impr